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4-1BB (TNFRSF9/CD137) belongs to the TNFR superfamily. 4-1BB is expressed by activated CD4 helper T cells, B cells, natural killer cells, natural killer T cells, dendritic cells, and activated endothelium. 4-1BB enhances tumor rejection by upregulating on T cells following activation and its engagement increases T cell proliferation and proinflammatory cytokine production. 

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